María Moriel‐Carretero

The DNA Damage Response kinase ATM restricts Golgi extension

This study shows ATM maintains Golgi morphology by counteracting excessive deployment and phosphorylating Golgi substrates, linking DDR kinases to Golgi biology.

Compromised DNA replication in gut cells underlies tardigrade sensitivity to genotoxic stress

This study identifies DNA replication as a critical vulnerability in tardigrades under genotoxic stress, showing that damage to dividing gut cells leads to midgut failure and death.

A CRISPR-Cas9-based system for the dose-dependent study of DNA double strand breaks sensing and repair

This paper introduces a CRISPR-Cas9-based system to induce controlled DNA double strand breaks (DSBs) in yeast and studies the behavior of the Tel1 kinase in response to these breaks.

Neutral lipids restrict the mobility of broken DNA molecules during comet assays

This study shows that neutral lipids in the nucleoid restrict DNA migration in comet assays and may regulate DNA dynamics in the nucleus.

SARS-CoV-2 predation of Golgi-bound PI4P primes the massive activation of the DNA Damage Response kinase ATM in the cytoplasm

This study shows SARS-CoV-2 hijacks Golgi-bound PI4P via OSBP1, leading to cytoplasmic ATM activation and impaired viral replication with ATM inhibitors.

Storage cell proliferation during somatic growth establishes that tardigrades are not eutelic organisms

This study shows that tardigrades undergo storage cell proliferation during growth, challenging the eutelic hypothesis and linking DNA replication to molting and survival.

PickPocket : Pocket binding prediction for specific ligands family using neural networks.

PickPocket predicts ligand-binding pockets for specific ligand families using neural networks, achieving >90% accuracy on fatty acid-like ligands with manually curated data.

A new role of the Mus81 nuclease for replication completion after fork restart

The paper shows that Mus81 is essential for resolving recombination intermediates during replication restart in G2/M phase, independent of DNA supercoiling and crosslinks.