Rosa E. Tolentino

Multiscale mapping of transcriptomic signatures for cardiotoxic drugs

The paper identifies cardiotoxic drug signatures using bulk transcriptomics and integrates them with genomic and single-cell data to predict toxicity mechanisms.

Central Nervous System axonal regeneration by spatially targeted drug combinations

This study identifies a four-drug combination that promotes axonal regeneration in the optic nerve of rats by targeting subcellular processes, leading to functional recovery.

Spinal Cord Injury regulates circular RNA expression in axons

The paper identifies SCI-induced changes in axonal RNA, including circular RNAs, and shows that reducing ADAR1 promotes axonal outgrowth.

Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration

The paper identifies extracellular histones as new inhibitors of CNS axonal regeneration, showing they induce growth cone collapse and can be reversed by activated protein C.

Systems therapeutics analyses identify genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer

The paper identifies genomic signatures predicting allopurinol and combination therapy responses in lung cancer using TCGA, CCLE, and patient-derived tumor data.

Lack of dynamic balance between vesicle transport and microtubule growth in neurite outgrowth enables formation of dystrophic bulbs

The paper uses simulations and experiments to show that imbalances between higher-level subcellular processes like vesicle transport and microtubule growth lead to dystrophic bulb formation in neurite outgrowth.