Author

Tessa Y. S. Le Large

Amsterdam University Medical CentersORCID 0000-0002-4273-7217Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Connie R. JiméneziD· 2 shared Richard R. de HaasiD· 2 shared Sander R. PiersmaiD· 2 shared Thang V. PhamiD· 2 shared Alex A. HennemaniD· 1 shared Andrea BertottiiD· 1 shared Anna WojtuszkiewicziD· 1 shared Bo WangiD· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBioinformatics

Connie R. JiménezORCID

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2 papers

Recent·Most cited

DPHL: A pan-human protein mass spectrometry library for robust biomarker discovery using Data-Independent Acquisition and Parallel Reaction Monitoring

Tiansheng Zhu, Yi Zhu, Yue Xuan, Huanhuan Gao, Xue Cai, Sander R. Piersma, Thang V. Pham, Tim Schelfhorst, Richard R. de Haas, Irene V. Bijnsdorp, Rui Sun, Liang Yue, Guan Ruan, Qiushi Zhang, Mo Hu, , Tiannan Guo

The paper introduces DPHL, a pan-human protein mass spectrometry library built using DIA and PRM, and demonstrates its utility in identifying differentially expressed proteins in prostate cancer and DLBCL.

Genomics Proteomics & Bioinformatics · Apr 1, 2020Peer-reviewedBioinformatics

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active phosphokinases

Robin Beekhof, Carolien van Alphen, Alex A. Henneman, Jaco C. Knol, Thang V. Pham, Frank Rolfs, Mariëtte Labots, Evan Henneberry, Tessa Y. S. Le Large, Richard R. de Haas, Sander R. Piersma, Valentina Vurchio, Andrea Bertotti, Livio Trusolino, Henk M.W. Verheul, Connie R. Jiménez

INKA identifies active phosphokinases in cancer by integrating kinase and substrate phosphorylation data from phosphoproteomics.

Molecular Systems Biology · Apr 1, 2019Peer-reviewedSystems Biology