Chin Cheng Huang

The paper uses CRISPR activation screens to identify proteoglycan core proteins, particularly SDC1, as key regulators of heparan sulfate sulfation and ligand specificity.

This study shows B3GNT7 regulates colonic mucus glycosylation, protects against colitis and infection, and has a distinct function from other B3GNT family members.

JAAG simplifies creating AlphaFold 3 JSON input files for glycan and macromolecule modeling by providing a web-based interface to reduce manual errors.