Eric J. Kremer

The paper identifies a specific neural circuit between the ACC and dlPAG that facilitates the affective component of pain, showing its role in aversive behaviors beyond pain.

This study shows that SCN2A deficiency in human brain assembloids disrupts cortico-striatal circuitry by impairing axonal projections and synaptic transmission, leading to hyperexcitability.

This study identifies aPVT D2+ neurons as critical for computing relative aversive and safety value signals during learning to guide value-based choices.

This study shows human Langerhans cells internalize and respond to adenovirus vectors, suggesting a role in vaccine-induced immunity.

This study shows that activating the MCC-dlPFC pathway in macaques increases foraging task engagement without changing trial-to-trial adaptive strategies.

This study shows that noradrenergic projections to the rodent orbitofrontal cortex are necessary for updating action-outcome relationships during reversal learning.

This study investigates how noradrenaline release within the Locus Coeruleus modulates cross-modular interactions through reciprocal inhibition and rebound activity.

This study shows that delivering a modified SCN1A gene via viral vectors to DS mice improves survival, reduces seizures, and corrects brain activity after symptom onset.

This study shows that locus-coeruleus norepinephrine activity determines the likelihood of sensory-evoked awakenings from sleep, with reduced activity during sleep suppressing responses to auditory stimuli.

This study identifies TrkB-expressing paraventricular hypothalamic neurons as key regulators of appetite through multiple neurocircuits, showing their role in suppressing food intake.

This study tests the use of CAV-2 vectors in a nonhuman primate cerebellum to identify afferent projections and assess retrograde transport.

The paper shows that spinal and prefrontal projecting locus coeruleus neurons in rats mediate distinct pain-related behaviors: analgesia vs. aversion and anxiety.