Jorge E. Contreras

This study shows that reducing S-nitrosylation of Cx43 in DMD mice prevents arrhythmias and myocardial injury under cardiac stress.

This study shows TRPV4 activation modulates endothelial Cx43 hemichannels via S-nitrosylation, influencing Ca2+ levels and vasomotor tone in resistance arteries.

The paper shows that connexin hemichannels can transport molecules independently of ion conduction, challenging the conventional view of their function.

This study shows that Cx43 hemichannels in astrocytes contribute to ALS progression and that blocking them can protect neurons and improve survival in ALS models.