Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features
Lisa Barros de Andrade e Sousa, Iris H. Jonkers, Laurène Syx, Ilona Dunkel, Julie Chaumeil, Christel Picard, Benjamin Forêt, Chongjian Chen, John T. Lis, Édith Heard, Edda G. Schulz, Annalisa Marsico
The paper predicts Xist-induced gene silencing kinetics using a Random Forest model based on epigenetic and genomic features, identifying key factors like distance to Xist and promoter pre-marking.
Genome Research · Jul 1, 2019Peer-reviewedGenomics