Charalampos Rallis

This study uses time-resolved growth tracking of fission yeast deletion mutants to identify genetic determinants of oxidative stress resistance.

The paper shows that pharmacological stress reveals hidden allelic background effects in genetic interaction screens, using fission yeast and Torin1 to demonstrate divergent fitness profiles.

This study identifies Bro1 as a central integrator linking TOR signalling to metabolic adaptation and longevity in fission yeast.

This study shows that compromised ESCRT signaling leads to resistance to Torin1 in fission yeast by preventing Torin1-induced degradation of transporters.

This study compares host metabolic and signaling responses to SARS-CoV-2 variants, finding that Omicron causes a more restrained response compared to pre-Omicron variants.

This study shows that rapalink-1, a mTOR inhibitor, extends lifespan in fission yeast by modulating an agmatinergic metabolic feedback circuit that regulates mTOR activity.

The paper shows that disrupting dNTP homeostasis is synthetically lethal with CDK-induced replication stress in fission yeast, leading to genome instability and cell death.

The paper identifies 5775 novel lncRNAs in fission yeast and characterizes their regulation by RNA-processing pathways.

The paper identifies natural genetic variants associated with longevity in fission yeast by analyzing segregant pools and genome sequencing during aging.

The paper investigates how structural variations in yeast genomes affect gene expression and quantitative traits, finding that copy number variants significantly influence phenotypes and reproductive isolation.

This study identifies pervasive alternative splicing in fission yeast, showing that exon-skipping transcripts are mostly non-functional and degraded by nuclear RNA surveillance.