Zhihua Chen

This study investigates the role of GlialCAM's cytoplasmic tail in white matter homeostasis using a mutant mouse model, revealing defects in ECM remodeling and glial activation.

The paper uses single-cell RNA sequencing and spatial profiling to identify signaling networks involved in neonatal brain hemorrhage development and resolution in mice.

This study identifies branched-chain keto acid accumulation in leptomeningeal disease CSF, showing immune suppression and neurodegeneration, and shows that reducing BCKA improves outcomes in mouse models.

This study identifies HAP40 as a conserved regulator of Huntingtin, showing it maintains HTT stability and modulates mutant HTT toxicity in both flies and human cells.