Author

Jan P. Gerlach

Radboud University NijmegenORCID 0000-0002-4445-3138Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Klaas W. MulderiD· 3 shared Hendrik G. StunnenbergiD· 2 shared Jessie A.G.L. van BuggenumiD· 2 shared Mark Hogeweg· 2 shared Sabine E.J. Tanis· 2 shared Agata RakszewskaiD· 1 shared Alexander van OudenaardeniD· 1 shared Branco M. H. HeutsiD· 1 shared

Activity by Year

2018-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersGenomics

Klaas W. MulderORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Wdr5, Brca1 and Bard1 link the DNA damage response to the mesenchymal-to-epithelial transition during early reprogramming.

Georgina Peñalosa-Ruiz, Vicky Bousgouni, Jan P. Gerlach, Susan Waarlo, Joris V. van de Ven, Tim Veenstra, José Silva, Simon J. van Heeringen, Chris Bakal, Klaas W. Mulder, Gert Jan C. Veenstra

The paper identifies Brca1, Bard1, and Wdr5 as factors linking DNA damage response to MET during reprogramming, using siRNA screening and colony morphology analysis.

Stem Cell Reports · Mar 14, 2019Peer-reviewedDevelopmental Biology

Combined quantification of intracellular (phospho-)proteins and transcriptomics from fixed single cells.

Jan P. Gerlach, Jessie A.G.L. van Buggenum, Sabine E.J. Tanis, Mark Hogeweg, Branco M. H. Heuts, Mauro J. Muraro, Lisa Elze, Francesca Rivello, Agata Rakszewska, Alexander van Oudenaarden, Wilhelm T. S. Huck, Hendrik G. Stunnenberg, Klaas W. Mulder

The paper introduces RAID, a method to analyze both transcriptomes and intracellular phosphoproteins from fixed single cells, showing its ability to detect heterogeneity in cellular responses.

Scientific Reports · Feb 6, 2019Peer-reviewedGenomics

Immuno-Detection by sequencing (ID-seq) enables large-scale high-dimensional phenotyping in cells.

Jessie A.G.L. van Buggenum, Jan P. Gerlach, Sabine E.J. Tanis, Mark Hogeweg, Pascal W.T.C. Jansen, Jesse Middelwijk, Ruud van der Steen, Michiel Vermeulen, Hendrik G. Stunnenberg, Cornelis A. Albers, Klaas W. Mulder

The paper introduces ID-seq, a technology that measures multiple molecular and cellular phenotypes in parallel, and uses it to study kinase inhibitor effects on human epidermal stem cells.

Nature Communications · Jun 13, 2018Peer-reviewedGenomics