Pascal W.T.C. Jansen

The paper develops a system to study PfEMP1, a key malaria parasite virulence factor, by generating parasites expressing a single PfEMP1 variant and enabling genome edits to investigate its function.

The paper identifies specific cPRC1 complexes, CBX4/PCGF4, that mediate oncogenic gene repression in DMG cells downstream of H3K27M mutation.

The paper determines the structure of the Pfs230:Pfs48/45 complex bound to transmission-blocking antibodies, revealing molecular interactions and epitopes that inform vaccine development.

The paper identifies and characterizes DNA methylation reader proteins in Arabidopsis thaliana, revealing context-specific binding preferences and functional roles.

This study investigates how varying ratios of HspB2 and HspB3 affect their phase behavior, revealing reversible condensates and aggregates with distinct molecular compositions.

The paper quantifies how chromatin context affects transcription factor binding affinities genome-wide and shows DNA accessibility is the main determinant.

The paper shows that Polycomb-mediated repression maintains spatial gene expression in zebrafish after body plan formation, with minimal global changes in gene expression.

This study identifies EZHIP as a novel cofactor of PRC2 that limits its activity in germ cells, leading to altered H3K27me2/3 deposition and impaired fertility in female mice.

The paper identifies ZMAT2 as a regulator of human epidermal differentiation through interactions with epigenetic modifiers and the pre-spliceosome, highlighting joint control of cell adhesion genes.

The paper introduces ID-seq, a technology that measures multiple molecular and cellular phenotypes in parallel, and uses it to study kinase inhibitor effects on human epidermal stem cells.