Author

Rebecca F. Gottesman

Johns Hopkins UniversityORCID 0000-0002-9504-1256Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 6 Research Focus:GWAS / association mapping· 4 Assay:GWAS summary statistics· 4 Assay:imaging· 2 Research Focus:differential expression· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1

Frequent Co-Authors

Philippe AmouyeliD· 4 shared Shuo LiiD· 4 shared Alexa BeiseriD· 3 shared Charles S DeCarliiD· 3 shared Claudia Liliana SatizábaliD· 3 shared David C M LiewaldiD· 3 shared Edith HoferiD· 3 shared M. Arfan IkramiD· 3 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetics

Philippe AmouyelORCID

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Author profile →

6 papers

Recent·Most cited

Spatial Patterns of White Matter Hyperintensities and Cognitive Function in Older Adults: A Community-Based Study

Xingyu Chen, Kei Nishimaki, Shuhei Tomoshige, Jill S. Chotiyanonta, Yuto Uchida, Bruce Alan Wasserman, Rebecca F. Gottesman, Eliseo Güallar, B. Gwen Windham, Kenichi Oishi

This study identifies spatial patterns of white matter hyperintensities (WMH) associated with cognitive decline in older adults using a community-based cohort.

bioRxiv · Oct 20, 2026 · PreprintNeuroscience

Synapse protein signatures in cerebrospinal fluid and plasma predict cognitive maintenance versus decline in Alzheimers disease

Hamilton Se‐Hwee Oh, Deniz Yagmur Urey, Linda Karlsson, Zeyu Zhu, Yuanyuan Shen, Amelia Farinas, Jigyasha Timsina, Michael R. Duggan, Jingsha Chen, Ian Hunter Guldner, Nader Morshed, Chengran Yang, Daniel Western, Muhammad Ali, Yann Le Guen, , Tony Wyss‐Coray

CSF YWHAG:NPTX2 synapse protein ratio, from proteomics of 3,416 individuals across six cohorts, explains cognitive impairment beyond amyloid and tau and predicts decline (hazard ratio 15.4).

Nature Medicine · Mar 31, 2025Peer-reviewedNeuroscience✦ In-depth digest

Genetic variants for head size share genes and pathways with cancer

Maria J. Knol, Raymond A. Poot, Tavia E. Evans, Claudia Liliana Satizábal, Aniket Mishra, Muralidharan Sargurupremraj, Sandra Van der Auwera, Marie‐Gabrielle Duperron, Xueqiu Jian, Isabel Charlotte Hostettler, Dianne H.K. van Dam-Nolen, Sander Lamballais, Mikołaj A. Pawlak, Cora Elizabeth Lewis, Amaia Carrión-Castillo, , Saud Alhusaini

This study identifies 67 genetic loci associated with head size, finding strong overlaps with cancer pathways and genes, suggesting shared genetic mechanisms between head growth and cancer risk.

Cell Reports Medicine · May 1, 2024Peer-reviewedGenomics

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants

Vincent Damotte, Sven J. van der Lee, Vincent Antoine Chouraki, Benjamin Grenier‐Boley, Jeannette M Simino, Hieab H.H. Adams, Giuseppe Tosto, Charles C. White, Natalie Terzikhan, Carlos Cruchaga, Maria J. Knol, Shuo Li, Susanna Schraen‐Maschke, Megan L. Grove, Claudia Liliana Satizábal, , Cornelia M. van Duijn

Alzheimer s & Dementia · May 18, 2021Peer-reviewedGenetics

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

Nicola J. Armstrong, Karen A. Mather, Muralidharan Sargurupremraj, Maria J. Knol, Rainer Malik, Claudia Liliana Satizábal, Lisa R. Yanek, Wen Wei, Vilmundur G. Gudnason, Nicole D Deuker, Lloyd T. Elliott, Edith Hofer, Neda Jahanshad, Shuo Li, Mark W. Logue, , Paul Nyquist

This study identifies genetic loci specific to periventricular and deep white matter hyperintensities, revealing distinct genetic architectures and potential biological mechanisms.

bioRxiv · Jun 27, 2019 · PreprintNeuroscience

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

Gail Davies, Max Lam, Sarah E. Harris, Joey W. Trampush, Michelle Luciano A, William David Hill, Saskia P. Hagenaars, Stuart James Ritchie, Riccardo Emilio Marioni, Chloe Fawns‐Ritchie, David C M Liewald, Judith A. Okely, Ari Ahola‐Olli, Catriona L. K. Barnes, Lars Bertram, , Luca Kleineidam

This study identifies 99 genetic loci associated with general cognitive function using data from 280,360 individuals, finding genes linked to brain structure and neurodegenerative disorders.

Nature Communications · May 22, 2018Peer-reviewedGenetics