Steven C. Munger

The Flame Retardant Triphenyl Phosphate Induces Varying Responses in Genetically Diverse Mouse Induced Pluripotent Stem Cells

The study examines how genetic variation in mouse induced pluripotent stem cells affects gene expression and cell cycle responses to triphenyl phosphate exposure.

A panel of Diversity Outbred mouse embryonic stem cells: enabling the functional characterization of natural genetic variation in vitro

The paper describes a panel of genetically diverse embryonic stem cells from Diversity Outbred mice to study natural genetic variation's impact on pluripotency and differentiation.

Chromosome X Dosage Modulates Development of Aneuploidy in Genetically Diverse Mouse Embryonic Stem Cells

The paper identifies that X chromosome dosage influences aneuploidy development in mouse embryonic stem cells, with XO and XY lines showing higher aneuploidy rates than XX lines.

Molecular and genetic heterogeneity in iPSCs derived from an outbred laboratory mouse population

The paper generates a genetically diverse panel of iPSCs from a mouse population and identifies regulatory loci influencing gene expression variation.

Simplifying Systems Genetics with QTLretrievR: An R Package for Molecular QTL Identification

QTLretrievR simplifies molecular QTL identification in genetically diverse populations by integrating existing tools with parallelization, reducing computational time and improving accessibility.

Mammalian oocytes receive maternal-effect RNAs from granulosa cells

The paper shows that growing mouse oocytes receive mRNAs from granulosa cells, which are enriched for transcripts important for oocyte maturation and early embryo development.

Cross cell-type systems genetics reveals the influence of eQTL at multiple points in the developmental trajectory of mouse neural progenitor cells

The paper identifies eQTL in mouse neural progenitor cells and shows their effects on gene regulation across developmental stages.

Imputation of 3D genome structure by genetic-epigenetic interaction modeling in mice

The paper uses regression modeling to identify genetic-epigenetic interactions in mice, showing they are common and structured by 3D chromatin domains.

Genetic dissection of the pluripotent proteome through multi-omics data integration

This study integrates multi-omics data from mouse embryonic stem cells to identify genetic drivers of proteome variability and uncover regulatory mechanisms in pluripotency.

Multi-omics analysis identifies drivers of protein phosphorylation

The paper identifies genetic drivers of protein phosphorylation using multi-omics data from mouse tissues, revealing novel interactions and targets of PDK1 in obesity and diabetes.

Genome-wide transcript and protein analysis reveals distinct features of aging in the mouse heart

The paper analyzes transcriptome and proteome data from aged mouse hearts to identify molecular changes associated with aging, revealing distinct biological processes and genetic loci influencing age-related changes.

An in vitro neurogenetics platform for precision disease modeling in the mouse

This paper develops a cross-species platform to model human disease using genetically diverse mouse and human stem cells, showing that DYRK1A loss of function effects vary with genetic background.

Genetic Control of Pluripotency Epigenome Determines Differentiation Bias in Mouse Embryonic Stem Cells

The paper shows genetic variation in mouse ESCs affects lineage commitment by modulating pluripotency epigenome regulators, with B6 and D2 strains showing distinct differentiation biases.

Regulation of protein abundance in genetically diverse mouse populations

The paper analyzes liver proteomes across three genetically diverse mouse populations to understand how genetic variation influences protein abundance and its relationship to phenotypes.

Genotype-free individual genome reconstruction of Multiparental Population Models by RNA sequencing data

The paper introduces GBRS, a method to reconstruct diploid genomes and quantify gene expression in multi-parent populations using RNA-Seq data without requiring genotype information.

Facial shape and allometry quantitative trait locus intervals in the Diversity Outbred mouse are enriched for known skeletal and facial development genes

This study identifies 37 QTL for facial shape in DO mice, finding enrichment for genes involved in skeletal and facial development, despite small individual effects.

Genetic variation influences pluripotent ground state stability in mouse embryonic stem cells through a hierarchy of molecular phenotypes

The paper identifies genetic variants influencing metastability in mouse embryonic stem cells by analyzing gene expression and chromatin accessibility in 185 genetically diverse cells.

Hierarchical Analysis of Multi-mapping RNA-Seq Reads Improves the Accuracy of Allele-specific Expression

EMASE improves ASE estimation by hierarchically allocating multi-mapping RNA-Seq reads, showing better performance than standard methods in simulations and detecting ASE in F1 hybrid mice.

Epistatic networks jointly influence phenotypes related to metabolic disease and gene expression in Diversity Outbred mice

The paper models epistatic networks in Diversity Outbred mice linking genetic variation, gene expression, and phenotypes related to metabolic disease and diet.