Fengtang Yang

This paper develops a population-genetic framework to infer double reduction and higher-order linkage disequilibrium in autopolyploids, revealing structured genomic architectures in natural and clonal populations.

This study resequences sable and pine marten genomes to reveal hybridization patterns, fertility, and genetic diversity, identifying candidate genes and divergence timing.

The paper presents a chromosome-level genome assembly of the Hispid cotton rat, annotating 24,878 protein-coding genes and identifying genetic innovations.

The paper analyzes 1,375 Malawi cichlid genomes to show that sex-linked chromosomal inversions drive adaptive speciation through introgression and selection on neuro-sensory, physiological, and reproductive genes.

This paper introduces an improved nanopore sequencing platform called CycloneSEQ, demonstrating long-duration sequencing and high yield with applications in genomics.

The paper presents a chromosome-scale genome of the Mongolian gerbil with sequenced centromeres, revealing new insights into centromere structure and heterochromatin distribution.

The paper identifies how SETX mutations cause genome instability in AOA2 by increasing transcription stress and impairing repair mechanisms.

The paper assembles the chromosomes of Schistosoma mansoni, revealing insights into the evolution of its ZW sex-determination system through gene annotation and synteny analysis.

The paper analyzes structural variation in the glycophorin gene cluster across 6466 genomes, identifies 15 known and 9 new variants, and links structural variants to recombination hotspots.

The paper analyzes structural variation in 911 human samples from 54 populations, identifying novel variants and introgressed elements, and highlights the need for diverse high-quality genomes.

This paper corrects FKRP mutations in iPSCs using CRISPR/Cas9, restoring functional glycosylation of α-dystroglycan in cortical neurons and validating the role of FKRP in dystroglycanopathies.

The paper shows that targeting tandem amplified regions in CRISPR-Cas9 screens reduces cellular fitness, while chromosomal duplications have minimal effects.

The paper identifies DUP4, a structural variant associated with reduced malaria risk and higher hemoglobin levels in a Tanzanian population.

The paper introduces Ragout, a reference-assisted assembly tool that improves chromosome assembly for large and complex genomes, achieving high accuracy with less than 5% unlocalized sequence.

The paper compares genome assemblies of Mus caroli and Mus pahari with Mus musculus and Rattus norvegicus to reveal lineage-specific evolutionary mechanisms, particularly repeat-associated processes.

The paper presents full-length de novo genome assemblies for 16 inbred mouse strains, identifying strain-specific haplotypes and novel functional loci, including a large unannotated gene with potential developmental roles.

This paper establishes expanded potential stem cells (EPSCs) from mouse blastomeres and shows they can contribute to both embryo proper and trophoblasts in chimeras.

This paper presents improved assemblies and gene annotations for the pig X and Y chromosomes, revealing evolutionary mechanisms and gene content differences compared to other mammals.

This study investigates the HSFY gene family in pigs and other suids, finding two amplified variants with potential roles in spermatogenesis and fertility.