Giulia Bertolin

TERT interacts with TFAM to activate mitochondrial fragmentation and auto/mitophagy

This study shows TERT interacts with TFAM to cause mitochondrial fragmentation and auto/mitophagy, affecting mitochondrial function and respiratory capacity.

Mitochondrial inner membrane partners of Aurora kinase A/AURKA and PHB2 shape organelle metabolic heterogeneity.

The paper identifies mitochondrial inner membrane proteins interacting with AURKA and PHB2, showing their role in shaping metabolic heterogeneity and mitochondrial morphology in cancer cells.

Combining FRET and super-resolution microscopy reveals kinase activation and mitochondrial activity at the nanoscale

The paper introduces BioSenSRRF, a method combining FRET biosensors with SRRF microscopy to study AURKA activation and mitochondrial activity at the nanoscale.

Development of capsaicin-derived prohibitin ligands to modulate the Aurora kinase A/PHB2 interaction and mitophagy in cancer cells

This study develops capsaicin-derived ligands that modulate the AURKA/PHB2 interaction and mitophagy in cancer cells, with compound 13 showing promise as a specific inhibitor of AURKA-dependent mitophagy.

Selective targeting of RalA with intrabodies impairs Triple Negative Breast Cancer metastasis

This paper develops RalA-specific intrabodies that inhibit mitochondrial fission and extracellular vesicle secretion, reducing metastasis in a TNBC mouse model.

Sex-specific loss of mitochondrial membrane integrity in the auditory brainstem of a mouse model of Fragile X syndrome

The paper investigates sex-specific mitochondrial membrane integrity differences in the auditory brainstem of a mouse model of Fragile X syndrome using fluorescence microscopy.

Aurora-A phosphorylates splicing factors and regulates alternative splicing

This study identifies Aurora-A as a splicing kinase that regulates alternative splicing by phosphorylating splicing factors and altering RNA motifs in affected regions.

Engineering of a fluorescent chemogenetic reporter with tunable color for advanced live-cell imaging

The paper engineers a fluorescent chemogenetic reporter with tunable color for live-cell imaging, enabling advanced spectral control and compatibility with advanced imaging techniques.

A comparison of high resolution image reconstruction methods from confocal array detector with a new deconvolution algorithm

The paper compares high-resolution image reconstruction methods for confocal microscopy, introducing a new deconvolution algorithm that improves resolution, contrast, and spatial intensity homogeneity.