Siân V. Owen

This study identifies host factors critical for ssRNA and ssDNA phage infection in E. coli, revealing conserved dependencies and lineage-specific requirements.

This study shows that prophage induction via SOS response limits resistance evolution to DNA-damaging antibiotics by eliminating mutants with high DNA damage.

Phage DisCo identifies phages that interact with specific bacterial traits by co-culturing strains with fluorescent tags and perturbations, using plaque morphology to detect infection inhibition.

The paper identifies a new sublineage of Salmonella Typhimurium ST313 in Malawi with a gene expression signature and increased fitness compared to its parent lineage.

The paper demonstrates a genetic code reassignment strategy that makes cells resistant to viral infections and prevents horizontal gene transfer by mistranslating viral proteins and relying on synthetic codons.

The paper identifies a non-coding SNP in the pgtE promoter of Salmonella ST313 that increases PgtE expression, contributing to serum resistance and virulence in a chicken model.