Cell BiologyJournal of Clinical InvestigationPeer-reviewed
Unrestrained fatty acid oxidation triggers heart failure in mice via cardiolipin loss and mitochondrial dysfunction
Chai-wan Kim, Goncalo Dias do Vale, Xiaorong Fu…·Jay D. Horton
This study shows that excessive fatty acid oxidation in mice leads to heart failure through cardiolipin loss and mitochondrial dysfunction, suggesting that increasing FAO may be harmful in heart failure.
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