Goncalo Dias do Vale

This study shows Salmonella LPS enhances fatty acid uptake in the mouse intestine via CD36 and myeloid TLR4, linking microbial sensing to lipid absorption and host defense.

This study shows that excessive fatty acid oxidation in mice leads to heart failure through cardiolipin loss and mitochondrial dysfunction, suggesting that increasing FAO may be harmful in heart failure.

This study shows dietary vitamin A enhances intestinal antimicrobial defenses by promoting REG3 lectin and defensin expression through retinoic acid receptor signaling.

This study identifies lipid metabolic reprogramming as a conserved mechanism conferring hypoxic and aging resilience in Arctic ground squirrels and C. elegans.

This paper shows that inhibiting ABHD11 reduces T cell cytokine production and alleviates autoimmunity by altering sterol metabolism and LXR activation.

This study identifies CLSTN3B as a key protein for adipocyte lipid droplet maturation by facilitating ER-LD contacts, enhancing lipid storage and metabolic health.

This paper identifies APMAP as an ER-localized antioxidant that maintains lipid and lipoprotein homeostasis, with loss of APMAP causing ER stress, lipid droplet accumulation, and altered lipoprotein maturation across multiple organisms.

This study investigates how the small intestinal epithelium integrates microbial and nutritional signals through transcriptional responses in mice, revealing distinct and overlapping regulatory mechanisms.