Jay D. Horton

This study shows that excessive fatty acid oxidation in mice leads to heart failure through cardiolipin loss and mitochondrial dysfunction, suggesting that increasing FAO may be harmful in heart failure.

This study identifies white adipose tissue lipolysis and circulating fatty acids as key mediators of metabolic tolerance to infection, showing improved survival in sepsis with beta3-adrenergic agonists.

The paper identifies a hepatic lipogenic metabolon that enhances fatty acid and triglyceride synthesis through post-translational regulation, suggesting it as a therapeutic target for metabolic liver diseases.