Author

Michael W. Nagle

Pfizer (United States)ORCID 0000-0002-4677-7582Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:GWAS / association mapping· 2 Assay:GWAS summary statistics· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Andrew P. MorrisiD· 2 shared Åsa K. HedmaniD· 2 shared Casey S. GreeneiD· 2 shared Cecilia M. LindgreniD· 2 shared Daniel HimmelsteiniD· 2 shared Erik IngelssoniD· 2 shared Gunnar EngströmiD· 2 shared Johan ÄrnlöviD· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenetics

Andrew P. MorrisORCID

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Author profile →

4 papers

Recent·Most cited

The probability of edge existence due to node degree: a baseline for network-based predictions

Michael Zietz, Daniel Himmelstein, Kyle Kloster, Christopher Williams, Michael W. Nagle, Casey S. Greene

The paper introduces a network permutation framework to assess how node degree influences edge prediction in biomedical networks and provides an edge prior as a baseline for performance evaluation.

GigaScience · Jan 1, 2024Peer-reviewedBioinformatics

Hetnet connectivity search provides rapid insights into how two biomedical entities are related

Daniel Himmelstein, Michael Zietz, Vincent Rubinetti, Kyle Kloster, Benjamin J. Heil, Faisal Alquaddoomi, Dongbo Hu, David N. Nicholson, Yun Hao, Blair D. Sullivan, Michael W. Nagle, Casey S. Greene

The paper introduces hetnet connectivity search to find meaningful relationships between biomedical entities in heterogeneous networks without requiring supervised training data.

GigaScience · Dec 28, 2022Peer-reviewedBioinformatics

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

Lasse Folkersen, Stefan Gustafsson, Qin Wang, Daniel Hvidberg Hansen, Åsa K. Hedman, Andrew Joseph Schork, Karen M. Page, Daria V. Zhernakova, Yang Wu, James E. Peters, Niclas Ericsson, Sarah E. Bergen, Thibaud Boutin, Andrew D. Bretherick, Stefan Enroth, , Anders Mälarstig

The paper identifies pQTLs for cardiovascular proteins and uses them to evaluate drug targets and suggest new candidates for precision medicine.

bioRxiv · Apr 3, 2020 · PreprintGenetics

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

Sonia H Shah, Albert Henry, Carolina Roselli, Honghuang Lin, Garðar Sveinbjörnsson, Ghazaleh Fatemifar, Åsa K. Hedman, Jemma B. Wilk, Michael P. Morley, Mark D. Chaffin, Anna Helgadóttir, Niek Verweij, Abbas Dehghan, Peter Almgren, Charlotte Andersson, , David J. Stott

This study conducts a large GWAS on heart failure, identifying 12 genetic loci with associations to CAD, atrial fibrillation, and reduced left ventricular function, and provides causal evidence for several risk factors.

bioRxiv · Jul 10, 2019 · PreprintGenetics