George J. Lu

Transcriptomic and proteomic responses to gas vesicle collapse in native and engineered bacterial systems

The paper investigates cellular responses to gas vesicle collapse using transcriptomic and proteomic analyses in native and engineered bacterial systems, revealing distinct stress responses and no clear protein recognition mechanism.

Temporal gene regulation enables controlled expression of gas vesicles and preserves bacterial viability

The paper develops a dual-inducer system to control gas vesicle expression in E. coli, preventing cell lysis and maintaining viability while enabling GV production.

Elucidating the assembly of gas vesicles by systematic protein-protein interaction analysis

The paper identifies protein-protein interactions among GV operon proteins to elucidate their assembly mechanism and establish potential protein complexes involved in gas vesicle formation.

Spatial Organization of Gas Vesicles is Governed by Phase-separable GvpU

The paper identifies GvpU as the protein governing gas vesicle clustering and shows how its phase transition behavior modulates cellular fitness and clustering states.

50-nm gas-filled protein nanostructures to enable the access of lymphatic cells by ultrasound technologies

This paper introduces 50-nm gas-filled protein nanostructures that can traverse biological barriers and access lymphatic cells via ultrasound technologies.

Structure of Anabaena flos-aquae gas vesicles revealed by cryo-ET

This study uses cryo-electron tomography to reveal the structure of Anabaena flos-aquae gas vesicles, showing how GvpA subunits form the shell and how GvpC provides structural reinforcement.