Qionghua Shen

Deciphering the Multiscale Morphology of Somatic Oncogenic Alterations in Hepatocellular Carcinoma

This study maps how distinct oncogenic drivers induce unique multiscale architectural changes in liver tissue, revealing mutation-specific remodeling across cellular and mitochondrial structures.

Altair-dvOPM: an open-access platform for large-field three-dimensional tissue imaging

Altair-dvOPM is an open-access microscope for large-field 3D tissue imaging, achieving micrometer resolution without custom objectives or specialized alignment.

Unraveling Subcellular Ultrastructure with Cyclically Multiplexed Expansion Microscopy

This paper introduces Cy-ExM, a high-plex imaging strategy that enables 3D super-resolution mapping of cellular ultrastructure in mammalian cells.

Multi-immersion Oblique Plane Microscope (miOPM): A reconfigurable platform for high-resolution Light-Sheet Fluorescence Microscopy.

The paper introduces miOPM, a reconfigurable LSFM platform that enables high-resolution imaging across multiple spatial scales and refractive indices.

Feature-Driven Whole-Tissue Imaging with Subcellular Resolution

The paper introduces MCT-ASLM, a microscopy platform that enables subcellular resolution imaging of whole tissues, demonstrating its application in studying neuronal circuits, kidney innervation, and tumor microenvironments.

Mechanically Sheared Axially Swept Light-Sheet Microscopy

The paper introduces a new image acquisition method for light-sheet microscopes that improves spatial context placement and reduces post-processing needs, achieving higher field of view and resolution.

Spatial Organization of Gas Vesicles is Governed by Phase-separable GvpU

The paper identifies GvpU as the protein governing gas vesicle clustering and shows how its phase transition behavior modulates cellular fitness and clustering states.

50-nm gas-filled protein nanostructures to enable the access of lymphatic cells by ultrasound technologies

This paper introduces 50-nm gas-filled protein nanostructures that can traverse biological barriers and access lymphatic cells via ultrasound technologies.