Author

Freddy Radtke

École Polytechnique Fédérale de LausanneORCID 0000-0003-4315-4045Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alain LamarreiD· 1 shared Albert C. MehliD· 1 shared Alexander TsouknidasiD· 1 shared Alison FarleyiD· 1 shared Anastasia I. KousaiD· 1 shared Burkhard LudewigiD· 1 shared Christian W. SiebeliD· 1 shared Clare C. BlackburniD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperImmunology

Alain LamarreORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintSep 5, 2026

The Notch signaling pathway is a master regulator of CD8+ T cell exhaustion and differentiation during chronic infection

Dave Maurice De Sousa, Salix Boulet, Frédéric Duval…·Nathalie Labrecque

This study shows that Notch signaling regulates CD8+ T cell exhaustion and differentiation during chronic infection by promoting the transition from progenitor to effector-like cells and preventing terminal exhaustion.

DOI 10.64898/2026.09.01.748651

mousescRNA-seq

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Developmental BiologybioRxivPreprintSep 30, 2022

Notch signaling pathway in tooth shape variations

Thimios A. Mitsiadis, Pierfrancesco Pagella, Helder Gomes Rodrigues…·Laurent Viriot

This study shows that Notch signaling, specifically through Jagged1, influences tooth-crown shape variations in mice, mirroring evolutionary changes observed in Muridae.

1 citation

mouseexperimental assay

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Developmental BiologyDevelopmentPeer-reviewedJan 1, 2020

Canonical NOTCH signaling controls the early progenitor state and emergence of the medullary epithelial lineage in fetal thymus development.

Dong Liu, Anastasia I. Kousa, Kathy E. O’Neill…·Clare C. Blackburn

This study shows NOTCH signaling regulates early thymic epithelial progenitor cells and mTEC lineage emergence during fetal thymus development.

40 citations

mouseexperimental assay

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