Haran Sivakumaran

The paper identifies 44 multi-cancer risk regions across four hormone-dependent cancers using GWAS and 3D chromatin mapping, annotating 53 candidate risk genes with potential therapeutic implications.

This study applies CRISPR interference to repress SmfgfrA in Schistosoma mansoni, showing reduced transcription, protein expression, and immune response, with durable effects on parasite development and host granuloma formation.

This paper uses CRISPR/Cas9 to edit the acetylcholinesterase gene in Schistosoma mansoni eggs, resulting in reduced AChE activity and decreased granuloma size in mice.

The paper maps chromatin interactions at 139 breast cancer risk signals using Capture Hi-C and identifies candidate target genes and functional mechanisms.

The paper identifies 14 genes, including NTN4, associated with breast cancer risk variants through allelic expression imbalance analysis.