Juliet D. French

HyDRA: a pipeline for integrating long- and short-read RNAseq data for custom transcriptome assembly

HyDRA integrates long- and short-read RNAseq data to improve transcriptome assembly, identifying over 50,000 new long noncoding RNAs in ovarian and fallopian tube samples.

GWAS and 3D chromatin mapping identifies multicancer risk genes associated with hormone-dependent cancers

The paper identifies 44 multi-cancer risk regions across four hormone-dependent cancers using GWAS and 3D chromatin mapping, annotating 53 candidate risk genes with potential therapeutic implications.

CRISPR interference for Sequence-Specific Regulation of Fibroblast Growth Factor Receptor A in Schistosoma mansoni

This study applies CRISPR interference to repress SmfgfrA in Schistosoma mansoni, showing reduced transcription, protein expression, and immune response, with durable effects on parasite development and host granuloma formation.

CRISPR/Cas9-mediated genome editing of Schistosoma mansoni acetylcholinesterase

This paper uses CRISPR/Cas9 to edit the acetylcholinesterase gene in Schistosoma mansoni eggs, resulting in reduced AChE activity and decreased granuloma size in mice.

Chromatin interactome mapping at 139 independent breast cancer risk signals

The paper maps chromatin interactions at 139 breast cancer risk signals using Capture Hi-C and identifies candidate target genes and functional mechanisms.

High-throughput allelic expression imbalance analyses identify candidate breast cancer risk genes

The paper identifies 14 genes, including NTN4, associated with breast cancer risk variants through allelic expression imbalance analysis.

Convergence of dispersed regulatory mutations predicts driver genes in prostate cancer

The paper identifies driver genes in prostate cancer by analyzing convergence of non-coding mutations in regulatory regions using 3D chromatin interactions and genomic data.