Author
QIMR Berghofer Medical Research InstituteORCID 0000-0002-8790-7793Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
3 papers
Recent·Most cited
Bingkuan Zhu, Yu Shen, Fang Luo, Chuan Su, Hong You, Xumin Zhang, Wei Hu
This study identifies SjCE2b as a critical elastase for Schistosoma japonicum cercariae skin penetration, showing it degrades host proteins and is neutralized by antibodies to reduce worm burden.
bioRxiv · Jul 16, 2026 · PreprintMicrobiology
Xiaofeng Du, Donald Peter McManus, Juliet D. French, Natasha Collinson, Haran Sivakumaran, Skye R. MacGregor, Conor E. Fogarty, Malcolm K. Jones, Hong You
This study applies CRISPR interference to repress SmfgfrA in Schistosoma mansoni, showing reduced transcription, protein expression, and immune response, with durable effects on parasite development and host granuloma formation.
Frontiers in Immunology · Jan 13, 2023Peer-reviewedMolecular Biology
Hong You, Johannes U. Mayer, Rebecca L. Johnston, Haran Sivakumaran, Shiwanthi L. Ranasinghe, Vanessa Rivera, Olga Kondrashova, Lambros T. Koufariotis, Xiaofeng Du, Patrick Driguez, Juliet D. French, Nicola Waddell, Mary Duke, Wannaporn Ittiprasert, Victoria H. Mann, , Donald Peter McManus
This paper uses CRISPR/Cas9 to edit the acetylcholinesterase gene in Schistosoma mansoni eggs, resulting in reduced AChE activity and decreased granuloma size in mice.
The FASEB Journal · Dec 18, 2020Peer-reviewedMolecular Biology