Amit Agarwal

Astrocyte redox imbalance underlies prelimbic neuronal hypoactivity and affective behavior in epilepsy

This study shows that astrocyte redox imbalance causes neuronal hypoactivity and affective behaviors in epilepsy, distinct from seizure mechanisms.

Cell-type-selective synaptogenesis during the development of excitatory connectivity in the mammalian neocortex

The paper shows that L6CThN neurons form functional synapses preferentially onto PV interneurons, establishing cell-type-specific excitatory connections in the neocortex.

Neuronal lysosome transfer to oligodendrocyte precursor cells: a novel mechanism of neuron-glia communication and its role in neurodegenerative disease

The paper identifies a novel neuron-glia communication mechanism where neurons transfer lysosomes to OPCs, linking this process to neurodegenerative disease progression.

Calcium-permeable AMPA receptors govern PV neuron feature selectivity

This study shows that calcium-permeable AMPA receptors (CP-AMPARs) in PV interneurons reduce their feature selectivity, and removing them increases selectivity in visual cortex and hippocampus.

Norepinephrine regulates Ca2+ signals and fate of oligodendrocyte progenitor cells in the cortex

The paper investigates how norepinephrine modulates Ca2+ signals and fate decisions in oligodendrocyte progenitor cells (OPCs) in the cortex through behavioral and genetic approaches.

Activation of β2-adrenergic receptors in microglia alleviates neuropathic hypersensitivity in mice

This study shows that activating β2-adrenergic receptors in microglia with Formoterol reduces neuropathic pain behaviors in mice by inhibiting microglial inflammation and structural changes.

Norepinephrine enhances oligodendrocyte precursor cell calcium dynamics in the cerebral cortex during arousal

This study shows norepinephrine modulates OPC calcium dynamics and lineage progression in vivo through adrenergic signaling.

Mitochondrial dysfunction and oxidative stress contribute to cognitive and motor impairment in FOXP1 syndrome

This study shows that mitochondrial dysfunction and oxidative stress in Foxp1+/- mice contribute to cognitive and motor impairments in FOXP1 syndrome.

Inhibition of neutral sphingomyelinase-2 facilitates remyelination

This study shows that inhibiting nSMase2 improves myelin quality by protecting oligodendrocytes during remyelination.