David Oxley

PTPRF is a stress responsive cytoskeletal checkpoint that coordinates metabolic adaptation in hepatocytes and β cells

This study identifies PTPRF as a stress-responsive cytoskeletal checkpoint that coordinates metabolic adaptation in hepatocytes and β cells by linking metabolic stress to actin reorganization.

Phosphoproteomics identifies the DYRK1B protein kinase as a regulator of processing bodies

This study identifies DYRK1B as a regulator of processing body abundance through phosphoproteomics and functional assays.

Loss of PTPRK in hepatocytes reduces steatosis and carcinogen-induced tumour development in obesity

This study shows that loss of PTPRK in hepatocytes reduces steatosis and tumour development in obesity-induced hepatocellular carcinoma.

An Nlrp5-null mutation leads to attenuated de novo methylation in oocytes, accompanied by a significant reduction in DNMT3L

This study shows that Nlrp5-null oocytes have reduced DNMT3L and impaired de novo methylation, leading to imprinting disorders and developmental issues.

Protein degradation shapes developmental tempo in mouse and human neural progenitors

The paper compares protein dynamics in mouse and human neural progenitors, finding that human NPs have longer protein half-lives and lower proteasomal activity, which influences developmental tempo.

Erosion of X-Chromosome Inactivation in female hiPSCs is heterogeneous and persists during differentiation

This study shows XCI erosion in female hiPSCs is common, heterogeneous, and persists during differentiation, affecting X-linked gene expression without altering DNA methylation levels.

Stability of Genomic Imprinting and X-Chromosome Inactivation in the Aging Brain

The paper examines genomic imprinting and X-chromosome inactivation stability in aging mouse brains, finding they remain largely stable despite epigenetic drift.

Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data

This study compares WGBS library preparation methods and identifies biases in sequencing data, finding that bisulfite conversion and PCR amplification are major sources of bias.