Christian Fredrick Baca

Brig3, a DNA glycosylase from a soil metagenome, excises 5-hydroxymethylcytosine from T-even phage DNA; the glucose hydrolase BapA extends defense to glucosylated genomes such as wild-type T4.

This study identifies MtvS1 and MtvS2 as regulators of the Francisella type V-A CRISPR-Cas system and shows they interact with RNA polymerase to modulate gene expression.

This study reveals how cyclic tetra-adenylate binds to Cap1, inducing conformational changes that open a membrane pore and cause depolarization during the type III CRISPR immune response.