Christopher Peralta

Brig3, a DNA glycosylase from a soil metagenome, excises 5-hydroxymethylcytosine from T-even phage DNA; the glucose hydrolase BapA extends defense to glucosylated genomes such as wild-type T4.

This study identifies KMT2E as a reader of H3K4me3Q5ser, showing its role in regulating chromatin dynamics and neurodevelopmental gene expression in ODLURO syndrome.

The paper identifies divergent mitochondrial and metabolic profiles between ALS-vulnerable and resilient neurons, revealing how these differences contribute to selective vulnerability in ALS.

This study examines how different exercise intensities affect the human plasma secretome and interorgan communication through multi-cohort interventions and multi-organ gene expression analysis.

The paper identifies DHRS3 as a lipid droplet protein that regulates melanoma cell state by modulating retinoid signaling.

The paper identifies dopaminylated proteins in the brain, including γCaMKII, and shows its role in synaptic-to-nuclear signaling and memory formation.

The paper presents cryo-EM structures of the Fanconi Anemia Core complex and its interaction with UBE2T, revealing the mechanism of FANCD2 and FANCI ubiquitination.

This study reveals the structural and functional role of mono-ubiquitination in the FANCI-FANCD2 complex, showing it forms a DNA clamp that facilitates ICL repair.