Cytoplasmic accumulation of FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and defects in inhibitory synapses
Jelena Scekic‐Zahirovic, Inmaculada Sanjuan-Ruiz, Vanessa W. Y. Kan, Salim Megat, Pierre De Rossi, Stéphane Dieterle, Raphaelle Cassel, Marguerite Jamet, Pascal Kessler, Diana Wiesner, Laura Tzeplaeff, Valérie Demais, Sonu Sahadevan, Katharina Hembach, Hans‐Peter Müller, , Luc Dupuis
This study shows that cytoplasmic FUS mislocalization in mice causes behavioral changes and inhibitory synaptic defects without widespread neuronal loss.
Nature Communications · May 21, 2021Peer-reviewedNeuroscience