Modulation of retroviral capsid assembly halts ARC-mediated TDP-43 intercellular spreading
Andrés Jiménez-Zúñiga, Alex M. Ascensión, Ángela Sánchez-Molleda, Irene Jiménez-Salvador, Martin Fuentetaja, Markel G. Ibarluzea, Rafael Ramis, Laura Rodríguez-Gómez, Haizea Hernández-Eguiazu, Maddi Alcain Dominguez, Jose Luis Zúñiga-Elizari, Saioa Moragón, Anabel Sáez-Mas, Lorea Blázquez, Vanesa Lafarga, , Gorka Gereñu
This study shows that ARC acts as a retroviral-like capsid for TDP-43 spreading in ALS and FTD, and that Lenacapavir blocks this process.
bioRxiv · Jul 18, 2026 · PreprintNeuroscience