Miguel Lafarga

The paper identifies a chemical inducer of ribophagy, SALSa, that reduces toxicity of ALS-related arginine-rich peptides and extends lifespan in a Drosophila model.

This paper shows a CTRB2 deletion variant increases pancreatic cancer risk by causing ER stress and inflammation in mice, using a new genetic model.

This paper investigates SMN deficiency in the SMNΔ7 mouse model of SMA, showing early non-atrophic myopathy with contractile and excitatory coupling defects in skeletal muscle before neurodegeneration.

This study identifies novel SETD8 inhibitors and shows their toxicity correlates with ribosome biogenesis regulators, suggesting a biomarker for targeted cancer therapy.

This study shows that GRN haploinsufficiency in FTD causes lysosomal and mitochondrial dysfunction, lipid metabolism changes, and autophagy impairment, which may contribute to disease pathogenesis.