Louise Lidemalm

A chemical inducer of ribophagy limits the toxicity of ALS-related arginine-rich peptides

The paper identifies a chemical inducer of ribophagy, SALSa, that reduces toxicity of ALS-related arginine-rich peptides and extends lifespan in a Drosophila model.

PI3K/mTOR activity sensitizes cancer cells to nucleolar stress

The paper identifies genetic factors that influence cancer cells' sensitivity to nucleolar stress-inducing drugs through CRISPR screens, revealing roles for P53, RB1, and PI3K/mTOR signaling.

The tyrosine kinase inhibitor GNF-7 targets senescent cells through allosteric activation of GCN2.

This study identifies GNF-7 as a senolytic drug that activates GCN2 to kill senescent cells, showing synergy with CDK4/6 inhibitors in preclinical models.

The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ

The paper identifies clofazimine as a drug that reduces polyQ toxicity by activating PPARγ, improving mitochondrial function in models of polyQ diseases.

Chemical and genetic screens identify new regulators of tetracycline-inducible gene expression system in mammalian cells

The paper identifies chemical and genetic regulators of the tetracycline-inducible gene expression system in mammalian cells, showing that FDA-approved drugs and genetic modifiers inhibit the system rather than alleviate TDP-43 toxicity.