Author

Serena Abbondante

University of California, IrvineORCID 0000-0002-9960-4079Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 6 Approach:experimental assay· 5 Organism:mouse· 4 Organism:bacteria (other)· 2 Organism:human· 2 Assay:proteomics· 2 Assay:spatial transcriptomics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Eric M. PearlmaniD· 6 shared Michaela Ellen MarshalliD· 6 shared Arne RietschiD· 2 shared Jolynn Tran Chau· 2 shared Mihaela G. GadjevaiD· 2 shared Nicole M. ChumbleriD· 2 shared Oscar A. NegróniD· 2 shared Amani Alvi· 1 shared

Activity by Year

2025-2026 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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6 shared papersMicrobiology

Eric M. PearlmanORCID

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6 papers

Recent·Most cited

Spatial transcriptomics identifies the Pseudomonas aeruginosa major outer membrane protein OprF as a critical factor in blinding corneal infections

Serena Abbondante, Hao Zhu, Nicole M. Chumbler, Oscar A. Negrón, Michaela Ellen Marshall, Ankush Tyagi, Arne Rietsch, Eric M. Pearlman, Mihaela G. Gadjeva

The paper identifies OprF as critical for Pseudomonas aeruginosa virulence in corneal infections by linking it to ExoT expression and ROS inhibition.

bioRxiv · May 20, 2026 · PreprintMicrobiology

Alpha hemolysin polymorphisms in methicillin-resistant Staphylococcus aureus clinical isolates regulate ADAM10-dependent neutrophil IL-1 beta secretion

Karl Liboro, Jolynn Tran Chau, James D Begando, Serena Abbondante, Angela Lackner, Yan Sun, Michaela Ellen Marshall, Nikitina Ly, Victor D. Johnson, George Dubyak, Michael S. Gilmore, Reginald McNulty, Camille André, Eric M. Pearlman

The paper shows that Hla polymorphisms in MRSA strains affect ADAM10-dependent neutrophil IL-1β secretion and corneal disease severity.

bioRxiv · Dec 14, 2025 · PreprintMicrobiology

An essential role for the Hv1 voltage-gated proton channel in Pseudomonas aeruginosa corneal infection

Priscila Rodriguez, Michaela Ellen Marshall, Jolynn Tran Chau, Jessica Abdelmeseh, Jamison L. Nourse, Francesco Tombola, Eric M. Pearlman, Serena Abbondante

The paper shows Hv1 is essential for neutrophil control of Pseudomonas aeruginosa corneal infection, despite increased ROS production in Hv1-deficient neutrophils.

Journal of Leukocyte Biology · Oct 18, 2025Peer-reviewedMicrobiology

A biofilm-tropic Pseudomonas aeruginosa bacteriophage uses the exopolysaccharide Psl as receptor

Brenna Walton, Serena Abbondante, Michaela Ellen Marshall, Justyna M. Dobruchowska, Amani Alvi, Larry A. Gallagher, Nikhil Vallikat, Zhemin Zhang, Daniel J. Wozniak, Edward W. Yu, Geert‐Jan Boons, Eric M. Pearlman, Arne Rietsch

The paper identifies a Pseudomonas aeruginosa bacteriophage, Clew-1, that uses Psl as a receptor to disrupt biofilms and reduce bacterial burden in a mouse model.

eLife · Aug 11, 2025Peer-reviewedMicrobiology

Virulence of Fusarium oxysporum strains causing corneal or plant disease is associated with their accessory chromosomes

Dilay Hazal Ayhan, Serena Abbondante, Domingo Martínez‐Soto, Siyuan Wu, Ricardo Rodríguez-Vargas, Shira Milo, Katherine Rickelton, Vista Sohrab, Shunsuke Kotera, Tsutomu Arie, Michaela Ellen Marshall, Marina Campos Rocha, Sajeet Haridas, Igor V. Grigoriev, Neta Shlezinger, , Li‐Jun Ma

This study compares two Fusarium oxysporum strains causing human and plant diseases, finding differences in virulence and accessory chromosomes associated with host adaptation.

mBio · Jun 26, 2025Peer-reviewedMicrobiology

Spatial transcriptomics identifies novel Pseudomonas aeruginosa virulence factors

Hao Zhou, Oscar A. Negrón, Serena Abbondante, Michaela Ellen Marshall, Brandon Jones, Edison Ong, Nicole M. Chumbler, Christopher D. Tunkey, Groves Dixon, Haining Lin, Obadiah J. Plante, Eric M. Pearlman, Mihaela G. Gadjeva

This study uses spatial transcriptomics to identify novel Pseudomonas aeruginosa virulence factors and host-pathogen interactions in ocular infection.

Cell Genomics · Mar 1, 2025Peer-reviewedMicrobiology