Christopher Brian Currin

This study uses a spiking neural network model with chloride dynamics to show that benzodiazepine efficacy in status epilepticus depends on GABAAR reversal potential and pyramidal cell chloride extrusion.

The paper uses computational models to determine the optimal placement of inhibitory synapses to minimize dendritic excitability by analyzing chloride dynamics and inhibitory accumulation.

This study shows that impaired spike generation and synaptic transmission in parvalbumin interneurons contribute to Dravet syndrome severity and chronic pathology in an experimental model.

The paper develops computational models to show how chloride dynamics affect neuronal input-output functions through changes in dendritic inhibition.

The paper uses biophysical models to show that cation-chloride cotransporters, not impermeant anions, primarily modulate chloride driving force in neurons.