Author

J. Patrick Loria

Yale UniversityORCID 0000-0002-4824-9089Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:protein folding & dynamics· 3 Approach:experimental assay· 2 Assay:protein structure· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Approach:mechanistic / dynamical model· 1 Assay:protein sequence· 1 Assay:proteomics· 1

Frequent Co-Authors

Alvan C. HenggeiD· 1 shared Apala ChaudhuriiD· 1 shared Danica S. CuiiD· 1 shared Dariia YehorovaiD· 1 shared Eric A. GaucheriD· 1 shared Erik ZavalaiD· 1 shared Evan O. AndersoniD· 1 shared Federica MaschiettoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBiochemistry

Alvan C. HenggeORCID

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Author profile →

3 papers

Recent·Most cited

Rewiring V-type and K-type enzyme allostery through subunit interface mutations

Apala Chaudhuri, Federica Maschietto, Olivia M. Enny, Víctor S. Batista, J. Patrick Loria

This paper identifies specific interfacial residues in IGPS that modulate allosteric regulation through structural and dynamic changes induced by targeted mutations.

bioRxiv · Jun 4, 2026 · PreprintBiophysics

Facilitating NMR Resonance Assignment with Metabolic Tampering

Danica S. Cui, Evan O. Anderson, Erik Zavala, George P. Lisi, J. Patrick Loria

This paper introduces a method to improve NMR resonance assignment by modulating metabolic flux during protein expression, using 15N-enriched media with natural abundance media to create unique peak patterns.

bioRxiv · May 1, 2026 · PreprintBiochemistry

Conformational Dynamics and Catalytic Backups in a Hyper-Thermostable Engineered Archaeal Protein Tyrosine Phosphatase

Dariia Yehorova, Nikolas Alansson, Ruidan Shen, Joshua Denson, Michael Robinson, Valeria A. Risso, Nuria Ramirez Molina, J. Patrick Loria, Eric A. Gaucher, José M. Sánchez‐Ruiz, Alvan C. Hengge, Sean J. Johnson, Shina Caroline Lynn Kamerlin

This paper describes an engineered archaeal PTP with enhanced thermostability and unique biochemical properties, revealing insights into enzyme evolution and biotechnological potential.

JACS Au · Dec 10, 2025Peer-reviewedBiochemistry