Author

Neranjan de Silva

Weill Cornell Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 3 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Todd EvansiD· 4 shared Kelly M. BanksiD· 2 shared Miriam GordilloiD· 2 shared Aadita Roy· 1 shared Ali NajiiD· 1 shared Catherine C. RobertsoniD· 1 shared Chendong PaniD· 1 shared Chengyang LiuiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersDevelopmental Biology

Todd EvansORCID

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Author profile →

5 papers

Recent·Most cited

A Versatile AAV-TH-SNCA Model to Study Early α-Synuclein Pathology and Intervention

Sabina Marciano, Leandra G. Velazquez, Claudia Rodríguez López, Neranjan de Silva, Garrett Sommer, William Tower, Eileen Ruth S. Torres, Michael G. Kaplitt, Teresa A. Milner, Roberta Marongiu

This paper develops an optimized AAV.TH.SNCA model to study early α-synuclein pathology in mice, showing that motor deficits and neurochemical changes occur before neuronal loss.

bioRxiv · Apr 30, 2026 · PreprintNeuroscience

3D Imaging with Superior Resolution Using Atacama Clear

Tansol Choi, Lauretta A. Lacko, Neranjan de Silva, Nang Kham Hsi Liang, Ying Liu, Edgar A. Jamies, Todd Evans, Romulo Hurtado

This paper introduces Atacama Clear (ATC), a 3D imaging technology that improves resolution and signal detection in cleared tissues, enabling better analysis of complex biological samples.

Cell Reports Methods · Mar 30, 2026Peer-reviewedMolecular Biology

GATA6 Mediates Endoderm and Mesoderm Progenitor Fate Driven by WNT and NODAL Signaling

Miriam Gordillo, Rebecca P. Wu, Kelly M. Banks, Neranjan de Silva, Todd Evans

This study shows GATA6 mediates endoderm and mesoderm progenitor fate by integrating NODAL and WNT signaling during gastrulation.

bioRxiv · Jun 20, 2025 · PreprintDevelopmental Biology

GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis

Joseph A. Bisson, Miriam Gordillo, Ritu Kumar, Neranjan de Silva, Ellen Yang, Kelly M. Banks, Zhong‐Dong Shi, Kihyun Lee, Dapeng Yang, Wendy K. Chung, Danwei Huangfu, Todd Evans

This study shows GATA6 regulates WNT and BMP programs in human precardiac mesoderm patterning, and modulating these pathways can rescue cardiomyocyte defects in GATA6 mutants.

eLife · Mar 13, 2025Peer-reviewedDevelopmental Biology

Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic β cell Pyroptosis upon Viral Infection

Liuliu Yang, Yuling Han, Tuo Zhang, Xue Dong, Jian Ge, Aadita Roy, Jiajun Zhu, Tiankun Lu, J. Jeya Vandana, Neranjan de Silva, Catherine C. Robertson, Jenny Xiang, Chendong Pan, Yanjie Sun, Jianwen Que, , Shuibing Chen

The paper develops vascularized macrophage-islet organoids to study immune-mediated β cell pyroptosis during viral infection and identifies TNFSF12-TNFRSF12A as a key mechanism.

Cell stem cell · Sep 2, 2024Peer-reviewedDevelopmental Biology