James E. Hassell

ApoE Lipidation State Directs Immunometabolic Reprogramming of Human Microglia

This study shows that ApoE4 lipidation state affects human microglial metabolism and function, with lipid-bound ApoE4 causing metabolic reprogramming and lipid-free ApoE4 inducing inflammatory signaling.

Locus Coeruleus-Amygdala Circuit Disrupts Prefrontal Control to Impair Fear Extinction

This study shows that stress and LC activation promote NE release in the BLA, disrupting vmPFC activity and impairing fear extinction.

A validated method for banking mixed glial cultures that yield responsive microglia

The paper validates a method to generate responsive microglia from frozen mixed glial cultures, showing similar functional responses to fresh cultures.

Olfactory and Trigeminal Routes of HSV-1 CNS Infection with Regional Microglial Heterogeneity

This study tracks HSV-1 spread from the nasal passages to the CNS in mice, revealing region-specific infection patterns and microglial responses.

Pharmacological stimulation of infralimbic cortex after fear conditioning facilitates subsequent fear extinction

This study shows that pharmacological activation of the infralimbic cortex after fear conditioning enhances fear extinction in rats.

Transcriptional profiling reveals potential involvement of microvillous TRPM5-expressing cells in viral infection of the olfactory epithelium

The paper identifies TRPM5-expressing microvillous cells in the olfactory epithelium as potentially involved in viral infection through transcriptional profiling.