Author

Jan A. Deprest

University College LondonORCID 0000-0002-4920-945XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Developmental Biology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:imaging· 2 Organism:rat· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Paolo De CoppiiD· 3 shared David BasurtoiD· 2 shared Emma Van den EedeiD· 2 shared Francesca Maria RussoiD· 2 shared Kanokwaroon WatananiruniD· 2 shared Luc JoyeuxiD· 2 shared Marianna ScugliaiD· 2 shared Simen VergoteiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersDevelopmental Biology

Paolo De CoppiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Intra-Abdominal Bowel Dilation in Experimental Gastroschisis is Associated with a Modifiable Transcriptomic Program of Intestinal Dysfunction

Mary Elizabeth Guerra, Tomohiro Arai, Luc Joyeux, Casey C. Baxter, Sourav Bose, Shiyanth Thevasagayampillai, Hui Li, Ling Yu, Varun Akondy, Marianna Scuglia, David Basurto, Emma Van den Eede, Simen Vergote, Kanokwaroon Watananirun, Wasinee Tianthong, , Sundeep Govind Keswani

The paper characterizes transcriptional changes in gastroschisis, showing that prenatal repair normalizes gene expression and bowel dilation.

Annals of Surgery · Aug 21, 2026Peer-reviewedDevelopmental Biology

A Reproducible Fetal Lamb Model of Complex Gastroschisis with Temporal Characterization of Bowel Changes

Tomohiro Arai, Michael Anthony Belfort, David Basurto, Marianna Scuglia, Kanokwaroon Watananirun, Wasinee Tianthong, Tom Bleeser, Marta Grinza, Simen Vergote, Emma Van den Eede, Michaël Aertsen, Bethany Fisher, Alex Menys, Theo Thijs, Inge Depoortere, , Luc Joyeux

This paper establishes a fetal lamb model of complex gastroschisis, showing it reproducibly induces structural and functional bowel changes at term, with higher incidence at later post-induction intervals.

bioRxiv · Mar 27, 2026 · PreprintDevelopmental Biology

Prenatal VEGF Nano-Delivery Reverses Congenital Diaphragmatic Hernia-Associated Pulmonary Abnormalities

Stavros Loukogeorgakis, Federica Michielin, Noura Al‐Juffali, Julio Jiménez, Soichi Shibuya, Jessica Allen-Hyttinen, Mary Patrice Eastwood, Ahmed S. N. Alhendi, Joseph Davidson, Eleonora Naldi, Panagiotis Maghsoudlou, Alfonso Tedeschi, Sahira Khalaf, Aziza Khabbush, Manuela Platé, , Paolo De Coppi

This paper investigates VEGF supplementation as a treatment for congenital diaphragmatic hernia (CDH)-associated lung abnormalities using an ex vivo model and nanoparticle-based delivery in vivo.

American Journal of Respiratory and Critical Care Medicine · Feb 18, 2025Peer-reviewedBioengineering

Proteomic Profiling of Hypoplastic Lungs Suggests an Underlying Inflammatory Response in the Pathogenesis of Abnormal Lung Development in Congenital Diaphragmatic Hernia

Richard Wagner, Paula Lieckfeldt, Hadeesha Piyadasa, Moritz Markel, Jan Riedel, Camelia Stefanovici, Nicole Peukert, Daywin Patel, Gabrielle Derraugh, Suyin A. Lum Min, Jan‐Hendrik Gosemann, Jan A. Deprest, Christopher D. Pascoe, Wai Hei Tse, Martin Lacher, , Richard Keijzer

The paper uses proteomic profiling to identify inflammatory processes as a key factor in the pathogenesis of lung hypoplasia in congenital diaphragmatic hernia.

Annals of Surgery · Aug 3, 2022Peer-reviewedDevelopmental Biology