Sarah E. Harris

This study identifies genetic and epigenetic factors associated with inflammatory protein levels in older adults using GWAS and EWAS with a Bayesian framework.

This paper introduces DNAm GrimAge, an epigenetic clock that predicts mortality and is associated with multiple brain health measures in older adults.

The paper analyzes whole genome sequencing data from an isolated Shetland population, finding increased ultra-rare variants in exonic and regulatory regions compared to mainland Scottish populations.

This study identifies neurology-related proteins in plasma associated with cognitive ability and brain volume in older adults, with partial mediation by brain volume.

This study identifies genetic and epigenetic factors associated with neurological protein levels in the Lothian Birth Cohort 1936, revealing potential causal links to neurological diseases.

This study uses polygenic scores to predict cognitive ability at age 70 and cognitive change from 70 to 79, finding limited predictive validity compared to APOE e4.

The paper investigates how linked mutations at adjacent nucleotides, termed sequential dinucleotide mutations, influence human population differentiation and protein evolution.

The paper replicates 55,000 DNA methylation QTLs using two cohorts and finds enrichment of trans mQTLs in specific genomic regions and complex traits.

The paper improves age prediction from DNA methylation using larger datasets, showing reduced error and limitations in capturing biological ageing variation.

This paper identifies genetic loci associated with retinal vascular tortuosity and links one of them to coronary artery disease risk.

This study examines the association between polygenic risk scores for neurodegenerative disorders and cognitive performance, finding lower cognitive performance with higher risk scores for AD, ALS, and FTD.

This study identifies 99 genetic loci associated with general cognitive function using data from 280,360 individuals, finding genes linked to brain structure and neurodegenerative disorders.

This study identifies six new Alzheimer's disease-associated loci using GWAS on family history data from UK Biobank and consortium data, with potential implications for precision medicine.

The paper identifies 116 independent genetic variants associated with neuroticism in over 329,000 UK Biobank participants and finds genetic correlations with mental health traits.

This study examines the genetic architecture of trail making test performance and its genetic correlations with cognitive functions in UK Biobank participants.

This study identifies 6 new blood pressure loci and 48 genes involved in BP regulation using GWAS and gene expression data from blood and kidney tissues.

The paper investigates rare disruptive variants in the DISC1 Interactome and Regulome, finding associations with schizophrenia and cognitive ability in psychiatric patients.

This study uses Mendelian randomization to examine causal relationships between cognitive ability, educational attainment, and physical health traits, finding no evidence of causation from health to cognitive ability or from educational attainment to health.

This study investigates the association between CpG methylation and educational attainment, finding limited significant associations that may be influenced by confounding factors.