Stuart James Ritchie

This study uses genomic PCA to identify shared genetic architecture between brain morphometry, ageing, and cognitive ability using UK Biobank data.

The paper introduces a gamified cognitive ability measure, Pathfinder, which shows heritability and genetic prediction of general cognitive ability.

This study identifies three dimensions of cortical ageing in the human brain and links the most general dimension to cognitive decline across multiple domains in older adults.

This study identifies lipid biomarkers associated with brain structure but not cognitive ability in older adults using metabolomic data from the LBC1936 cohort.

This study evaluates how different network thresholding methods affect structural brain network properties and their association with age in the UK Biobank.

This study identifies genetic loci associated with household income and links them to biological pathways and cognitive ability, showing genetic differences between income and education.

The paper examines how aging affects brain network integrity and its association with cognitive function using MRI data from two cohorts.

This study compares within- and between-family polygenic score predictions for eight life outcomes in DZ twins, finding that cognitive traits show greater between-family prediction, which is explained by socio-economic status.

This study examines associations between vascular risk factors and brain MRI indices in UK Biobank, finding that higher vascular risk is linked to poorer brain health across macro- and microstructural measures.

This study uses polygenic scores to predict cognitive ability at age 70 and cognitive change from 70 to 79, finding limited predictive validity compared to APOE e4.

The paper develops DNA methylation predictors for BMI, smoking, alcohol, and education, finding they explain some phenotypic variance and predict mortality for some traits.

The paper examines the association between brain peak width of skeletonised mean diffusivity (PSMD) and cognitive domains, finding it correlates with processing speed but not more strongly than other brain imaging measures or cognitive domains.

The paper examines resting-state brain connectivity in UK Biobank data and finds associations with cognitive performance, educational attainment, and household income.

This study identifies 99 genetic loci associated with general cognitive function using data from 280,360 individuals, finding genes linked to brain structure and neurodegenerative disorders.

Structural equation modeling over GWAS summary statistics fits several traits jointly; across five psychiatric traits it surfaced 27 SNPs the univariate GWASs missed and sharpened polygenic scores.

Across 5,216 UK Biobank adults, males had larger brain volumes and surface areas, females thicker cortices and stronger default-mode connectivity; male variance was generally greater.

This study uses MTAG to combine GWAS of education and income with a GWAS of intelligence, identifying 107 loci and 233 genes associated with intelligence.

The paper matches 73- and 92-year-olds for childhood intelligence, social background, and brain size, finding significant structural brain differences linked to cognitive decline.