Pippa A. Thomson

Atypical energy-related symptoms define biologically distinct subtypes of major depressive disorder

The paper identifies biologically distinct subtypes of MDD based on energy-related symptoms and finds genetic and metabolic differences between them.

Methylome-wide association studies of traumatic injury identifies differential DNA methylation of synaptic plasticity and GABAergic-signalling.

The paper identifies differential DNA methylation patterns associated with traumatic injury in individuals with MDD compared to controls, highlighting synaptic plasticity and GABAergic-signalling pathways.

Characterisation and Genetic Architecture of Major Depressive Disorder Subgroups Defined by Weight and Sleep Changes

This study characterizes MDD subgroups based on weight and sleep changes, finding distinct clinical and genetic profiles, including novel associations with epilepsy and immunometabolic genes.

Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction

The paper investigates the impact of a t(1;11) translocation on white matter integrity and oligodendrocyte-myelin function using DTI and cellular models.

Genome-wide by environment interaction studies (GWEIS) of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland.

This study performs genome-wide association studies and genome-wide by environment interaction studies of depressive symptoms and stress in UK Biobank and Generation Scotland, identifying genetic and gene-environment interactions associated with depression.

A validation of the diathesis-stress model for depression in Generation Scotland.

This study validates the diathesis-stress model for depression by showing gene-environment interaction effects, particularly in women, using data from Generation Scotland.

Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

This study identifies a genetic variant associated with stress-sensitivity and shows it improves prediction of major depressive disorder using polygenic risk scores.

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

The paper investigates the genetic and environmental contributions to stressful life events and their overlap with depression and neuroticism using a large family-based sample.

Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank

This study performs genome-wide meta-analyses of depression in two large cohorts, finding one significant locus and suggesting larger sample sizes may be more informative than phenotypic stratification.

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

This study performs a genome-wide haplotype-based association analysis for major depressive disorder using two cohorts, identifying significant haplotypes potentially linked to the disorder.

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

This study investigates shared genetic architecture between subcortical brain volumes and MDD using GWAS data from multiple cohorts, finding a non-significant positive genetic correlation for hippocampal volume.

Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

The paper investigates rare disruptive variants in the DISC1 Interactome and Regulome, finding associations with schizophrenia and cognitive ability in psychiatric patients.

Shared genetics and couple-associated environment are major contributors to the risk of both clinical and self-declared depression

This study identifies shared genetic and couple-associated environmental factors contributing to both clinical and self-declared depression risks.