Julia Bos

Replication coordination marks the domestication of large extrachromosomal replicons in bacteria

This study identifies two categories of extrachromosomal replicons in bacteria and shows that large replicons replicate in sync with the chromosome and use its replication machinery for stable inheritance.

Extracellular vesicle production and membrane uptake promote repair and antibiotic tolerance in E. coli

This study shows that extracellular vesicles in E. coli sequester and remove antibiotics, repair membranes, and enhance survival without conferring resistance.

Sedentary chromosomal integrons as biobanks of bacterial anti-phage defence systems

The paper identifies anti-phage defence systems encoded by sedentary chromosomal integron cassettes in Vibrio cholerae, showing 16 cassettes provide phage resistance.

Cassette recombination dynamics within chromosomal integrons are regulated by toxin-antitoxin systems.

The paper shows toxin-antitoxin systems regulate cassette recombination dynamics in chromosomal integrons by killing cells when excision rates are too high.