Romain Koszul

The paper investigates chromatin state reorganization during leg regeneration in pancrustaceans, finding a conserved sequence of chromatin resetting and pioneer factor activation across species.

This study deletes nine NAPs from E. coli to create a strain lacking native chromatin, revealing gene expression homogenization and demonstrating that bacterial life can proceed without chromatin proteins.

This study identifies two categories of extrachromosomal replicons in bacteria and shows that large replicons replicate in sync with the chromosome and use its replication machinery for stable inheritance.

The paper investigates the 3D genome structuration and dynamics of bacteriophage PAK_P3 during infection of Pseudomonas aeruginosa, revealing specific interactions between phage and host genomes.

The paper introduces momics, a framework for integrating multi-omics genomic data, showing improved compression, speed, and performance in deep learning for chromatin accessibility prediction.

This study maps transcriptional activity and chromosome architecture in Bdellovibrio bacteriovorus across its predatory lifecycle stages using multi-omics approaches.

This study identifies a CST complex-mediated post-resection NHEJ repair pathway that promotes intermediate deletions while preventing larger deletions and rearrangements.

Hicberg reconstructs contact signals from repeated elements in genomes by statistically reassigning reads from Hi-C data, revealing new insights into their impact on chromosome architecture.

This study investigates the role of HU in chromosome organization and replication in Streptococcus pneumoniae, showing it promotes long-range interactions and supports replication and segregation.

The paper presents the first chromosome-level genome assembly of Flaccisagitta enflata, providing a resource for comparative genomic studies in Chaetognatha and Gnathifera.

Cyclin O is necessary for multiciliated cells to enter their differentiation cell cycle variant and allows the massive amplification of centrioles, which serve as basal bodies for cilia nucleation.

The paper uses Micro-C to map DNA-DNA contacts in Plasmodium falciparum, revealing heterochromatic and euchromatic structures mediated by MORC/ApiAP2 and other factors.

The paper introduces the tidyCoverage R package for managing and analyzing epigenomic coverage data, enhancing reproducibility and accessibility in genome-wide analysis workflows.

The paper identifies a new cell cycle variant in multiciliated cells that enables centriole amplification without DNA replication or mitosis.

This study presents a chromosome-level genome assembly for the European Green Woodpecker, Picus viridis, using short and long-read sequencing combined with Hi-C scaffolding.

The paper shows that sister chromatid cohesion inhibits cohesin-mediated DNA loop expansion during G2 phase.

The paper shows V. cholerae MatP structures and delays segregation of both chromosomes independently of tetramer formation and divisome interaction.

The paper investigates how transcription and cohesin complexes influence genome organization in yeast, showing transcription induces DNA borders and loops independently of SMC complexes.

A de novo yeast neochromosome carrying all 275 tRNA genes was built and characterized; it imposes a growth burden, with genome doubling and deletions in haploids possibly reflecting compensation.

The paper identifies how the 2μ plasmid in yeast binds to inactive chromosomal regions through nucleosome signals and RNA Pol II depletion, revealing a stable and rapid tethering mechanism.

The paper shows that absence of Red1 and Hop1 recruitment prevents meiotic recombination on a chromosome arm containing the sex locus in Lachancea kluyveri, affecting genome evolution and fitness.

The paper synthesizes a shorter yeast chromosome and studies its fusion with other chromosomes, revealing new 3D structural interactions and Red1 binding patterns.

The paper investigates whether neuroinvasion and anosmia are independent outcomes of SARS-CoV-2 infection by analyzing clinical, olfactory, and neuroinflammatory responses in infected golden hamsters.

This study shows that bacterial chromosomes can undergo chromatin assembly, activity, looping, and compartmentalization in yeast, driven by their sequence composition.

The paper develops a statistical mechanics model called SPI to analyze recombination patterns in synthetic yeast chromosomes generated by SCRaMbLE, finding a random walk scaling exponent between 0.45 and 0.6.

The paper presents chromosome-scale genome assemblies of Acanthamoeba castellanii and shows infection-induced chromatin reorganization during Legionella pneumophila infection.

The paper presents chromosome-level genome assemblies for two hybridogenetic lineages of Cataglyphis hispanica using long-read sequencing and 3C data, enabling studies of thermal adaptation and reproductive systems.

The paper presents a chromosome-level genome assembly for the European flat oyster, providing insights into its genetics and potential for aquaculture improvement.

The paper investigates how Scc2, Smc3 acetylation, and Pds5 regulate cohesin-dependent chromatin loop expansion during the cell cycle.

This study shows cohesin promotes cis dsDNA over-sampling during homology search in yeast by blocking cohesin progression and enabling loop expansion-coupled scanning.