Author
The Francis Crick InstituteORCID 0000-0002-5000-0995Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Ohm Prakash, Tomas B Voisin, Alzbeta Roeselova, Cecilie M Jorgensen, James S Desmet, Andrea Nans, Rick Davies, Louise Jane Walport, David Balchin
The paper identifies cyclic peptides that selectively bind to a cotranslational folding intermediate of β-galactosidase, revealing a druggable pocket formed during translation.
bioRxiv · Nov 2, 2026 · PreprintBiochemistry
Laura Karpauskaite, Tomas B. Voisin, Sarah Maslen, Lois Kent, Grant A. Pellowe, Mark J. Skehel, David Balchin
The paper investigates how chaperones like Hsp70, Hsp90, and TRiC bind to nascent p53 during translation, showing TRiC's specificity and how mutations affect this process.
bioRxiv · Apr 21, 2026 · PreprintBiochemistry
Alžběta Roeselová, Santosh Shivakumaraswamy, Gabija Jurkeviciute, Jessica Zhiyun He, Josef Johannes Auburger, Jaro L. Schmitt, Günter Kramer, Bernd Bukau, Radoslav Ivanov Enchev, David Balchin
The paper shows that the ribosome coordinates folding and assembly of a complex protein to enable efficient biogenesis.
Molecular Cell · Jan 19, 2026Peer-reviewedBiochemistry
Alžběta Roeselová, Sarah Maslen, Jessica Zhiyun He, Gabija Jurkeviciute, Aleksandra Pajak, Mark J. Skehel, Radoslav Ivanov Enchev, David Balchin
This study investigates how GroEL/ES interacts with nascent proteins on ribosomes, showing that GroEL binds and destabilizes substrates, while GroES facilitates partial encapsulation and refolding.
Nature Communications · Nov 13, 2025Peer-reviewedBiochemistry
Grant A. Pellowe, Tomas B. Voisin, Laura Karpauskaite, Sarah Maslen, Alžběta Roeselová, Mark J. Skehel, Chloë Roustan, Roger George, Andrea Nans, Svend Kjær, Ian A. Taylor, David Balchin
The paper investigates how the human ribosome modulates multidomain protein folding by delaying domain docking, contrasting with bacterial ribosomes.
Nature Structural & Molecular Biology · Sep 19, 2025Peer-reviewedBiochemistry