Author

Alžběta Roeselová

The Francis Crick InstituteORCID 0000-0002-0175-6462Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 3 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

David BalchiniD· 3 shared Gabija Jurkeviciute· 2 shared Jessica Zhiyun He· 2 shared Mark J. SkeheliD· 2 shared Radoslav Ivanov EncheviD· 2 shared Sarah MasleniD· 2 shared Aleksandra PajakiD· 1 shared Andrea NansiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

David BalchinORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis

Alžběta Roeselová, Santosh Shivakumaraswamy, Gabija Jurkeviciute, Jessica Zhiyun He, Josef Johannes Auburger, Jaro L. Schmitt, Günter Kramer, Bernd Bukau, Radoslav Ivanov Enchev, David Balchin

The paper shows that the ribosome coordinates folding and assembly of a complex protein to enable efficient biogenesis.

Molecular Cell · Jan 19, 2026Peer-reviewedBiochemistry

GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome

Alžběta Roeselová, Sarah Maslen, Jessica Zhiyun He, Gabija Jurkeviciute, Aleksandra Pajak, Mark J. Skehel, Radoslav Ivanov Enchev, David Balchin

This study investigates how GroEL/ES interacts with nascent proteins on ribosomes, showing that GroEL binds and destabilizes substrates, while GroES facilitates partial encapsulation and refolding.

Nature Communications · Nov 13, 2025Peer-reviewedBiochemistry

RNA-binding proteins provide specificity to the PAN2-PAN3 mRNA deadenylation complex

Terence T. L. Tang, Francesco Zangari, Conny Wing-Heng Yu, James A. W. Stowell, Alžběta Roeselová, Stefan M.V. Freund, Anne‐Claude Gingras, Lori A. Passmore

This study shows that the PAN2-PAN3 deadenylation complex can be recruited to specific mRNAs via RNA adaptors, adding to the specificity of mRNA degradation.

bioRxiv · Sep 27, 2025 · PreprintMolecular Biology

The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking

Grant A. Pellowe, Tomas B. Voisin, Laura Karpauskaite, Sarah Maslen, Alžběta Roeselová, Mark J. Skehel, Chloë Roustan, Roger George, Andrea Nans, Svend Kjær, Ian A. Taylor, David Balchin

The paper investigates how the human ribosome modulates multidomain protein folding by delaying domain docking, contrasting with bacterial ribosomes.

Nature Structural & Molecular Biology · Sep 19, 2025Peer-reviewedBiochemistry