This study uses cryo-ET and sub-tomogram averaging to analyze Ty1 virus-like particles, revealing diverse capsomere arrangements and the role of CA-CTD flexibility in VLP heterogeneity.

bioRxiv · Dec 18, 2025 · PreprintBiophysics

The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking

Grant A. Pellowe, Tomas B. Voisin, Laura Karpauskaite, Sarah Maslen, Alžběta Roeselová, Mark J. Skehel, Chloë Roustan, Roger George, Andrea Nans, Svend Kjær, Ian A. Taylor, David Balchin

The paper investigates how the human ribosome modulates multidomain protein folding by delaying domain docking, contrasting with bacterial ribosomes.

Nature Structural & Molecular Biology · Sep 19, 2025Peer-reviewedBiochemistry

Structural and functional characterization of the KHNYN extended-diKH domain for mediating ZAP antiviral activity

Rebecca L Youle, María José Lista, Clément R. Bouton, Simone Kunzelmann, Harry Wilson, M.A. Cottee, Andrew G. Purkiss, Elizabeth R. Morris, Stuart J. D. Neil, Ian A. Taylor, Chad M. Swanson

This study characterizes the KHNYN ex-diKH domain's role in ZAP antiviral activity, revealing its structural features and identifying a potential protein-protein interaction site.

Journal of Biological Chemistry · Feb 19, 2025Peer-reviewedMicrobiology