Lisa Mapelli

Targeted Antisense Oligonucleotide Treatment Rescues Developmental Alterations in Spinal Muscular Atrophy Organoids

This study shows that early ASO treatment rescues developmental defects in SMA organoids by restoring SMN levels and correcting splicing defects.

Design, implementation, and functional validation of a new generation of microneedle 3D high-density CMOS multi-electrode array for brain tissue and spheroids

The paper introduces a 3D high-density CMOS multi-electrode array with microneedles for improved recording from 3D brain tissue and spheroids, showing enhanced signal quality and tissue vitality.

Non-linear frequency-dependence of neurovascular coupling in the cerebellar cortex implies vasodilation-vasoconstriction competition

The paper investigates neurovascular coupling in the cerebellar cortex and finds non-linear frequency dependence due to competition between vasodilation and vasoconstriction pathways.

Deletion of calcineurin from GFAP-expressing astrocytes impairs excitability of cerebellar and hippocampal neurons through astroglial Na+/K+ ATPase.

This study shows that deleting calcineurin in astrocytes impairs neuronal excitability in the cerebellum and hippocampus by reducing Na+/K+-ATPase activity.

Hyper-excitability and hyper-plasticity disrupt cerebellar signal transfer in the IB2 KO mouse model of autism

The paper investigates neuronal and circuit properties in IB2 KO mice, showing hyper-excitability and hyper-plasticity disrupt cerebellar signal transfer, supporting cerebellar involvement in ASD.