The paper identifies MEIS1 as a gene involved in sleep abnormalities and cerebellar development using cross-species variant-to-function analyses in zebrafish.

2 citations

zebrafishCRISPR screen

𝕏 PostBluesky

NeurosciencebioRxivPreprintJun 16, 2026

Cross-trait clustering of sub-threshold sleep genetic signals identifies EGR2 as a conserved regulator of sleep

Kyla D. Mace, Bao Khanh Trang, Amber J. Zimmerman…·Matthew S. Kayser

The paper identifies EGR2 as a conserved sleep regulator by analyzing sub-threshold genetic signals across sleep-related traits in multiple species.

DOI 10.64898/2026.06.12.731887

humanDrosophila

𝕏 PostBluesky

GeneticsbioRxivPreprintApr 9, 2026

Cell-specific variant-to-gene mapping identifies conserved neural and glial regulators of sleep

Amber J. Zimmerman, Samaneh Biglari, Bao Khanh Trang…·Alex C. Keene

The paper identifies cell-type-specific genes regulating sleep by mapping GWAS variants to effector genes in human and Drosophila models, revealing ruby/AP3B2 as a conserved glial regulator.

DOI 10.64898/2026.04.07.715910

humanDrosophila

𝕏 PostBluesky

NeuroscienceNature CommunicationsPeer-reviewedJan 12, 2026

Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2

Kyla D. Mace, Amber J. Zimmerman, Alessandra Chesi…·Matthew S. Kayser

The paper identifies beat-Ia/CADM2 as a gene involved in hypersomnia by showing its role in sleep regulation across species and demonstrates potential therapeutic targets.

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Drosophilazebrafish

𝕏 PostBluesky